Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 18391961.
- Also identified by DOI 10.1038/nm1752 and PMC identifier 2656682.
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Abstract
Postmortem analysis of five subjects with Parkinson's disease 9-14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies.
Medical subject headings
- Brain Tissue Transplantation
- Fetal Tissue Transplantation
- Neurons
- Parkinson Disease