Anti-anginal efficacy of intravenous amlodipine assessed by means of atrial pacing.
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Abstract
The anti-anginal efficacy of amlodipine was investigated in patients with angina pectoris by means of atrial pacing during cardiac catheterization. Intravenous administration of amlodipine significantly increased the time to pacing-induced angina and reduced the area of ST-segment change for an equivalent pacing rate, suggesting an improvement in this functional marker of ischaemia. In addition, a significant reduction in the double product suggests that amlodipine reduced myocardial oxygen consumption.
Medical subject headings
- Angina Pectoris
- Calcium Channel Blockers
- Cardiac Pacing, Artificial
- Nifedipine