A tRNA with oncogenic capacity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18394985.
- Also identified by DOI 10.1016/j.cell.2008.03.017.
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Abstract
Overexpression of Brf1, a transcription factor of the RNA polymerase III apparatus, can transform cells in vitro and cause tumor formation in vivo. Marshall et al. (2008) now show that one of the transcriptional products of RNA polymerase III, the initiator tRNA(Met), mediates this effect, revealing an unexpected role for this tRNA in tumorigenesis.
Medical subject headings
- Cell Transformation, Neoplastic
- RNA, Transfer, Met