Bruton and Tec: new links in osteoimmunology.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18396132.
- Also identified by DOI 10.1016/j.cmet.2008.03.013.
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Abstract
Enhanced and deficient immune responses are associated with abnormal bone homeostasis. A new study by Shinohara et al. (2008) shows that protein phosphorylation by the tyrosine kinases Bruton and Tec links immunity and bone as well as two signaling pathways in precursors of osteoclasts, the cells that degrade bone.
Medical subject headings
- Bone and Bones
- Osteoblasts
- Osteoclasts
- Protein-Tyrosine Kinases