Abnormal transforming growth factor-beta expression in mesenchymal stem cells from patients with osteoarthritis.
basic_science · Level V
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Abstract
To determine the expression of the genes that code for the isoforms of transforming growth factor-beta (TGF-beta) and TGF-beta receptors (TBR) in mesenchymal stem cells (MSC) from patients with osteoarthritis (OA). Total RNA was extracted from primary cultures of MSC and quantitative real-time reverse transcription-polymerase chain reaction was performed to analyze gene expression. MSC from patients with OA showed significantly increased total TGF-beta, TGF-beta1 isoform, TBR-II, and TBR-III mRNA expression compared to controls. Our study is the first reporting the gene expression levels of TGF-beta and its isoforms and receptors in patients with OA. These findings might have pathological significance for OA disease.
Medical subject headings
- Mesenchymal Stem Cells
- Osteoarthritis, Knee
- Receptors, Transforming Growth Factor beta
- Transforming Growth Factor beta