Mobilisation of mesenchymal cells in cardiac patients: is intense exercise necessary?
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 18400877.
- Also identified by DOI 10.1136/bjsm.2007.044693.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Circulating mesenchymal cells (cMCs) have a potential for regenerating damaged tissue, e.g., ischaemic myocardium. In patients (age range: 53-76 years) with stable coronary artery disease cMCs were determined before and after dynamic exercise of moderate (< respiratory compensation threshold (RCT)) (n = 9 patients) or high intensity (>RCT) (n = 11). Only high-intensity exercise (i.e., provoking signs of myocardial ischaemia in 3 patients and ventricular extrasystoles in another) induced a significant increase in cMCs (p = 0.009). These results support the hypothesis that intense exercise (near or at the point of myocardial ischaemia) is a potent stimulus for MC mobilisation.
Medical subject headings
- Cell Movement
- Coronary Artery Disease
- Exercise Therapy
- Mesenchymal Stem Cells