Urinary loss of erythropoietin after intravenous versus subcutaneous epoetin-beta in preterm infants.

Langer, Juliane; Obladen, Michael; Dame, Christof · J Pediatr · 2008

prospective_cohort · Level II

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Abstract

Hematopoietic and non-hematopoietic effects of recombinant erythropoietin (Epo) given to preterm infants are controversially discussed. Because renal loss of Epo was significantly higher after intravenous versus subcutaneous Epoetin-beta administration, we suggest a reconsideration of whether subcutaneous recombinant Epo is more efficient and safer because of lower peaks of circulating Epo.

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