Quantifying collagen in mouse kidneys.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 18414435.
- Also identified by DOI 10.1038/ki.2008.70.
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Abstract
Identification of genes underlying quantitative trait loci (QTLs) represents a formidable task. Recent advances in the annotation of the mouse genome and the availability of newly developed mouse strains should boost gene discovery. Kato and colleagues report the localization of a QTL for collagen type I deposition in kidneys on mouse chromosome 2, representing the first step for the identification of a gene involved in interstitial fibrosis, an important pathway in progression to end-stage renal failure in many kidney disorders.
Medical subject headings
- Collagen Type I
- Kidney
- Quantitative Trait Loci