Role for alkaline phosphatase as an inducer of vascular calcification in renal failure?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18414436.
- Also identified by DOI 10.1038/ki.2008.104.
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Abstract
Vascular calcification is associated with increased cardiovascular morbidity and mortality. A number of calcification inhibitors have been defined recently, including inorganic pyrophosphate (PP(i)), an important physicochemical inhibitor of hydroxyapatite crystal growth. Increased hydrolysis of PP(i) by tissue-nonspecific alkaline phosphatase (TNAP) may occur in renal failure and act to enhance mineralization of vessels.
Medical subject headings
- Alkaline Phosphatase
- Calcinosis
- Renal Insufficiency
- Vascular Diseases