Nanogap detector inside nanofluidic channel for fast real-time label-free DNA analysis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18416580.
- Also identified by DOI 10.1021/nl080473k.
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Abstract
We report fabrication and characterization of a novel real-time, label-free DNA detector, that uses a long nanofluidic channel to stretch a DNA strand and a nanogap detector (with a gap as small as 9 nm) inside the channel to measure the electrical conduction perpendicular to the DNA backbone as it moves through the gap. We have observed electrical signals caused by 1.1 kilobase-pair (kbp) double-stranded (ds)-DNA passing through the gap in the nanogap detectors with a gap equal to or less than 13 nm.
Medical subject headings
- DNA
- Electrochemistry
- Microfluidics
- Nanotechnology
- Oligonucleotide Array Sequence Analysis
- Sequence Analysis, DNA