Culture-Negative intracerebral abscesses in children and adolescents from Streptococcus anginosus group infection: a case series.

Petti, Cathy A; Simmon, Keith E; Bender, Jeffrey; Blaschke, Anne; Webster, Kathleen A; Conneely, Mark F; Schreckenberger, Paul C; Origitano, Thomas C et al. · Clin Infect Dis · 2008

case_series · Level IV

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Abstract

We report the use of 16S ribosomal RNA gene amplification and sequencing to diagnose culture-negative intracerebral abscesses in younger patients. These 3 cases demonstrate the optimal application of gene sequencing from direct specimens for patients with negative culture results compromised by antibacterial therapy but histories highly suggestive of acute bacterial infection.

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