Rethinking pseudokinases.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18423189.
- Also identified by DOI 10.1016/j.cell.2008.04.005 and PMC identifier 6226312.
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Abstract
Pseudokinases lack conservation of one or more of the catalytic residues in the kinase core and as a consequence are typically thought to be catalytically inactive. New work by Mukherjee et al. (2008) challenges this assumption. They show that the pseudokinase domain of CASK (Ca2+/calmodulin activated serine-threonine kinase) adopts an active conformation and displays catalytic activity in vivo.
Medical subject headings
- Guanylate Kinases