A TRIFfic perspective on acute lung injury.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18423191.
- Also identified by DOI 10.1016/j.cell.2008.04.006 and PMC identifier 7112263.
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Abstract
Acute lung injury (ALI) is a leading cause of death in people infected with H5N1 avian influenza virus or the SARS-coronavirus. Imai et al. (2008) now report that ALI is triggered by the signaling of oxidized phospholipids through Toll-like receptor 4 (TLR4) and the adaptor protein TRIF. These findings provide insight into the molecular pathogenesis of ALI, a condition for which treatment options are currently very limited.
Medical subject headings
- Adaptor Proteins, Vesicular Transport
- Respiratory Distress Syndrome
- Toll-Like Receptor 4