Changing patterns in HIV reverse transcriptase resistance mutations after availability of tenofovir.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 18426370.
- Also identified by DOI 10.1086/588045.
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Abstract
Assessment of 1177 human immunodeficiency virus (HIV) resistance genotypes at an HIV/AIDS clinic showed a decrease in the incidence of the K65R mutation, from 15.2% of isolates during the period 2002-2004 to 2.7% of isolates during the period 2005-2006 (P < .001), despite elevated and stable rates of tenofovir use. A reduction in the rate of coadministration of didanosine (from 41.6% of patients in 2004 to 0.8% of patients in 2006; P < .001) largely explained this observation.
Medical subject headings
- Anti-HIV Agents
- Drug Resistance, Multiple, Viral
- HIV Infections
- HIV Reverse Transcriptase
- Reverse Transcriptase Inhibitors