Infection of cultured human endothelial cells by Legionella pneumophila.
basic_science · Level V
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- Record sourced from PubMed, PMID 18431493.
- Also identified by DOI 10.1371/journal.pone.0002012 and PMC identifier PMC174114.
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Abstract
Legionella pneumophila is a gram-negative pathogen that causes a severe pneumonia known as Legionnaires' disease. Here, we demonstrate for the first time that L. pneumophila infects and grows within cultured human endothelial cells. Endothelial infection may contribute to lung damage observed during Legionnaires' disease and to systemic spread of this organism.