A new generation of high flex life polyurethane urea for polymer heart valve--studies on in vivo biocompatibility and biodurability.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18431755.
- Also identified by DOI 10.1002/jbm.a.31937.
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Abstract
Development of new generation high flex life polyurethane urea (HFL18-PU) with appropriate elastic modulus, biocompatibility, blood compatibility, resistant to calcification, and biodurability for the long-term use as cardiac device is still a challenge. This study reports the development of a fully aliphatic, ether-free physically cross-linked and low elastic modulus (6.841 +/- 0.27 MPa) polyurethane urea having in vivo biostability, in vivo biocompatibility and high flex-life (721 +/- 30 million cycles) that can satisfy the requirements for the fabrication of tri-leaflet heart valve.
Medical subject headings
- Biocompatible Materials
- Heart Valve Prosthesis
- Polyurethanes