gpDB: a database of GPCRs, G-proteins, effectors and their interactions.
basic_science · Level V
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- Record sourced from PubMed, PMID 18441001.
- Also identified by DOI 10.1093/bioinformatics/btn206.
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Abstract
gpDB is a publicly accessible, relational database, containing information about G-proteins, G-protein coupled receptors (GPCRs) and effectors, as well as information concerning known interactions between these molecules. The sequences are classified according to a hierarchy of different classes, families and subfamilies based on literature search. The main innovation besides the classification of G-proteins, GPCRs and effectors is the relational model of the database, describing the known coupling specificity of GPCRs to their respective alpha subunits of G-proteins, and also the specific interaction between G-proteins and their effectors, a unique feature not available in any other database. http://bioinformatics.biol.uoa.gr/gpDB CONTACT: shamodr@biol.uoa.gr Supplementary data are available at Bioinformatics online.
Medical subject headings
- Database Management Systems
- Databases, Protein
- GTP-Binding Proteins
- Information Storage and Retrieval
- Protein Interaction Mapping
- Receptors, G-Protein-Coupled
- Sequence Analysis, Protein