The mych gene is required for neural crest survival during zebrafish development.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18446220.
- Also identified by DOI 10.1371/journal.pone.0002029 and PMC identifier 2323570.
- Licence recorded as CC0.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
BACKGROUND: Among Myc family genes, c-Myc is known to have a role in neural crest specification in Xenopus and in craniofacial development in the mouse. There is no information on the function of other Myc genes in neural crest development, or about any developmental role of zebrafish Myc genes. PRINCIPAL FINDINGS: We isolated the zebrafish mych (myc homologue) gene. Knockdown of mych leads to severe defects in craniofacial development and in certain other tissues including the eye. These phenotypes appear to be caused by cell death in the neural crest and in the eye field in the anterior brain. SIGNIFICANCE: Mych is a novel factor required for neural crest cell survival in zebrafish.
Medical subject headings
- Neural Crest
- Transcription Factors
- Zebrafish
- Zebrafish Proteins