Substrate selectivity APPLies to Akt.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18455980.
- Also identified by DOI 10.1016/j.cell.2008.04.015.
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Abstract
The protein kinase Akt occupies a central position in multiple signaling pathways. Although numerous Akt substrates have been identified, less is known about the factors that regulate specific cellular responses to Akt signaling. In this issue, Schenck et al. (2008) demonstrate that the endosomal protein Appl1 modulates Akt's substrate selectivity to promote cell survival during zebrafish development.
Medical subject headings
- Proto-Oncogene Proteins c-akt
- Signal Transduction
- Zebrafish
- Zebrafish Proteins