A different TIPE of immune homeostasis.
editorial · Level V
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- Record sourced from PubMed, PMID 18455981.
- Also identified by DOI 10.1016/j.cell.2008.04.017 and PMC identifier 2750003.
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Abstract
Proteins with death effector domains (DED) are key signal transducers involved in cell death and inflammation. In this issue of Cell, Sun et al. (2008) describe TIPE2, a DED protein that negatively regulates both T cell receptor and Toll-like receptor signaling. These findings reveal a new element critical to the maintenance of homeostasis in both the adaptive and innate immune systems.
Medical subject headings
- Homeostasis
- Immunity, Innate
- Intracellular Signaling Peptides and Proteins