The CAMplexities of central ghrelin.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18460326.
- Also identified by DOI 10.1016/j.cmet.2008.04.009.
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Abstract
The gut hormone ghrelin is known to activate hypothalamic AMPK, a crucial metabolic sensor controlling energy balance. In this issue of Cell Metabolism, Anderson et al. (2008) show that CaMKK2 mediates this effect by forming a unique complex of AMPKalpha/beta with acetyl-CoA carboxylase (ACC) in a pathway distinct from the more established AMP/LKB1 pathway.
Medical subject headings
- Acetyl-CoA Carboxylase
- Appetite Regulation
- Calcium-Calmodulin-Dependent Protein Kinase Kinase
- Energy Metabolism
- Ghrelin
- Hypothalamus
- Protein Kinases