Type 3 deiodinase in hypoxia: to cool or to kill?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18460327.
- Also identified by DOI 10.1016/j.cmet.2008.04.008.
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Abstract
Type 3 deiodinase (D3) inactivates thyroid hormones. Simonides et al. (2008) now report that hypoxia-induced D3 activation leads to reduction of 3,5,3'-triiodothyronine (T3) and oxygen consumption, suggesting that D3 activation is a component of cellular responses to hypoxia and supporting the idea of cell-specific regulation of thyroid hormone levels by deiodinases.
Medical subject headings
- Hypoxia
- Iodide Peroxidase