Cutaneous cancer stem cells: beta-catenin strikes again.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18462688.
- Also identified by DOI 10.1016/j.stem.2008.04.011.
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Abstract
Cancer stem cells (CSCs) are a subpopulation of tumor cells that retain properties of tissue-specific stem cells, including the ability to self-renew. In a recent article in Nature, Malanchi et al. (2008) identified a population of CD34(+) cells in epidermal tumors that require beta-catenin signaling to maintain a CSC phenotype.
Medical subject headings
- Neoplastic Stem Cells
- Signal Transduction
- Skin Neoplasms
- beta Catenin