Open chromatin and hypertranscription in embryonic stem cells.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18462689.
- Also identified by DOI 10.1016/j.stem.2008.04.006.
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Abstract
In this issue of Cell Stem Cell, Efroni et al. (2008) use tiling microarrays to reveal genome-wide hypertranscription in mouse embryonic stem cells (ESCs), including expression of normally silent, noncoding regions. Hypertranscription may reflect the unusual "open" structure of ESC chromatin.
Medical subject headings
- Embryonic Stem Cells
- Transcription, Genetic
- Transcriptional Activation