Small interfering RNA-mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema.
basic_science · Level V
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- Record sourced from PubMed, PMID 18469825.
- Also identified by DOI 10.1038/nm1772.
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Abstract
Neurodegeneration and brain edema are hallmarks of human malignant brain tumors. Here we show that genetic or pharmacological inhibition of the glutamate transporter xCT (X(c-) system, encoded by SLC7a11) in vivo leads to abrogated neurodegeneration, attenuated perifocal edema and prolonged survival. These results show a crucial role for xCT in glioma-induced neurodegeneration and brain edema, corroborating the concept that edema formation may be in part a consequence of peritumoral cell death.
Medical subject headings
- Amino Acid Transport System y+
- Brain Edema
- Gene Silencing
- Glioma
- Neurodegenerative Diseases
- RNA, Small Interfering