Interstitial chromosomal deletion within 4q11-q13 in a human hepatoma cell line.
basic_science · Level V
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Abstract
Southern blot analysis revealed the presence of an aberrant albumin gene as well as a normal one in a human hepatoma cell line, HuH-7. A genomic sequence carrying this altered gene was isolated and characterized. This clone contains a 3-kbp 3' segment of the albumin gene linked to a non-albumin sequence at intron 11. The non-albumin sequence is assigned to chromosome 4q12-q13 by in situ hybridization. This indicates an interstitial deletion of a chromosomal segment within 4q11-q13 because the albumin gene is mapped there. The truncated albumin gene is detected in an early passage of HuH-7 cells and has been maintained stably in cell culture.
Medical subject headings
- Carcinoma, Hepatocellular
- Chromosome Deletion
- Chromosomes, Human, Pair 4
- Liver Neoplasms