DeTEKting ubiquitination of APC/C substrates.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18485863.
- Also identified by DOI 10.1016/j.cell.2008.04.034.
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Abstract
Regulated protein degradation by the ubiquitin-proteasome pathway ensures the unidirectionality of mitotic progression by removing cell-cycle regulators required at earlier stages. The APC/C ubiquitin-protein ligase targets proteins by appending polyubiquitin degradation signals that are subsequently recognized by the 26S proteasome. Reporting in this issue, Jin et al. (2008) identify a TEK motif in both ubiquitin and substrates of APC/C that mediates assembly of these degradation signals.
Medical subject headings
- Proteins
- Ubiquitin
- Ubiquitin-Protein Ligase Complexes