A metabolic throttle regulates the epigenetic state of rDNA.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18485866.
- Also identified by DOI 10.1016/j.cell.2008.04.026.
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Abstract
The synthesis of ribosomal RNA (rRNA) is carefully tuned to match nutritional conditions. In this issue, Murayama et al. (2008) describe a mechanism that couples the energy status of the cell to heterochromatin formation and silencing of rRNA genes. They show that an altered NAD(+)/NADH ratio in response to glucose starvation regulates the silencing activity of eNoSC, a complex consisting of the NAD(+)-dependent histone deacetylase SIRT1, the histone methyltransferase SUV39H1, and a new protein called nucleomethylin (NML). These results suggest a mechanism that links cell physiology to rDNA silencing, which in turn is a prerequisite for nucleolar integrity and cell survival.
Medical subject headings
- DNA, Ribosomal
- Energy Metabolism
- Epigenesis, Genetic