Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus.
basic_science · Level V
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Abstract
Autoreactive T lymphocytes are clonally deleted during maturation in the thymus. Deletion of T cells expressing particular receptor V beta elements is controlled by poorly defined autosomal dominant genes. A gene has now been identified by expression of transgenes in mice which causes deletion of V beta 14+ T cells. The gene lies in the open reading frame of the long terminal repeat of the mouse mammary tumour virus.
Medical subject headings
- Genes, Viral
- Mammary Tumor Virus, Mouse
- Receptors, Antigen, T-Cell
- T-Lymphocytes