Nanofluidic biosensing for beta-amyloid detection using surface enhanced Raman spectroscopy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18489171.
- Also identified by DOI 10.1021/nl0808132 and PMC identifier 2587305.
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Abstract
Trace detection of the conformational transition of beta-amyloid peptide (Abeta) from a predominantly alpha-helical structure to beta-sheet could have a large impact in understanding and diagnosing Alzheimer's disease. We demonstrate how a novel nanofluidic biosensor using a controlled, reproducible surface enhanced Raman spectroscopy active site was developed to observe Abeta in different conformational states during the Abeta self-assembly process as well as to distinguish Abeta from confounder proteins commonly found in cerebral spinal fluid.
Medical subject headings
- Amyloid beta-Peptides
- Biosensing Techniques
- Microfluidic Analytical Techniques
- Nanotechnology
- Spectrum Analysis, Raman
- Surface Plasmon Resonance