Regulated import and degradation of a cytosolic protein in the yeast vacuole.
basic_science · Level V
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Abstract
The key regulatory enzyme in gluconeogenesis, fructose 1,6-bisphosphatase (FBPase) is subject to glucose-stimulated proteolytic degradation in Saccharomyces cerevisiae. This process involves the regulated transfer of FBPase directly from the cytosol into the vacuole or a vacuole-related organelle. Glucose may regulate the production of an FBPase receptor or import factor that is transported to the vacuole through the secretory pathway.
Medical subject headings
- Endopeptidases
- Fructose-Bisphosphatase
- Saccharomyces cerevisiae
- Vacuoles