Lipopolysaccharide-induced monocytic cell death for the diagnosis of mild neonatal-onset multisystem inflammatory disease.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 18492537.
- Also identified by DOI 10.1016/j.jpeds.2008.01.038.
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Abstract
In this report, we describe a boy who showed mild symptoms of neonatal-onset multisystem inflammatory disease. Although his symptoms and laboratory findings were similar to those of systemic juvenile idiopathic arthritis, further examinations revealed papilledema, meningitis, and a NLRP3 mutation. His peripheral blood monocytes died within 24 hours after lipopolysaccharide stimulation, a test that may be useful for diagnosis even in mild cases.
Medical subject headings
- Inflammation
- Lipopolysaccharides
- Monocytes