Cystatin C as a marker of cognitive function in elders: findings from the health ABC study.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 18496846.
- Also identified by DOI 10.1002/ana.21383 and PMC identifier 2584446.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
We determined whether serum cystatin C, a novel measure of kidney function that colocalizes with brain beta-amyloid, is associated with cognition among 3,030 elders. Those with high cystatin C (n = 445; 15%) had worse baseline scores on Modified Mini-Mental State Examination or Digit Symbol Substitution Test (p <or= 0.02) compared with those with intermediate/low level and 7 years greater decline (p <or= 0.04). Incident cognitive impairment (decline >or=1.0 standard deviation) was greatest among those with high cystatin C (Modified Mini-Mental State Examination: 38 vs 25%; adjusted odds ratio, 1.92; 95% confidence interval, 1.37-2.69; Digit Symbol Substitution: 38 vs 26%; odds ratio, 1.54; 95% confidence interval, 1.10-2.15).
Medical subject headings
- Aging
- Alzheimer Disease
- Brain
- Cognition Disorders
- Cystatins
- Kidney Diseases