Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis".
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18497277.
- Also identified by DOI 10.1126/science.1152366.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate-2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals.
Medical subject headings
- Brain
- Intracellular Signaling Peptides and Proteins
- Longevity
- Phosphoproteins