Nano-biopower supplies for biomolecular motors: the use of metabolic pathway-based fuel generating systems in microfluidic devices.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18497920.
- Also identified by DOI 10.1039/b801033a.
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Abstract
We report fuel generation systems for molecular motors based on pyruvate kinase, or for the first time, mitochondria, implemented within microfluidic devices. Intact organelles acted as bio-nanopower supplies for molecular motors, using isolated mitochondria to convert chemical energy from succinate to ATP, harnessing nature's enzymatic transformation cascades directly. Motors were activated essentially equally by ATP produced by pyruvate kinase, mitochondria, or direct addition of ATP.
Medical subject headings
- Adenosine Triphosphate
- Energy-Generating Resources
- Microfluidic Analytical Techniques
- Mitochondria
- Nanotechnology
- Pyruvate Kinase
- Succinic Acid