Neurofibrillary tangles in dementia pugilistica are ubiquitinated.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 1850450.
- Also identified by PMC identifier 1014344.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Ubiquitin, a protein thought to be involved in the ATP-dependent non-lysosomal degradation of abnormal proteins, has already been identified as a component of neurofibrillary tangles in Alzheimer's disease. We have examined ubiquitin immunoreactivity in a unique collection of brains from 16 ex-boxers including 11 with dementia pugilistica. Neurofibrillary tangles of dementia pugilistica were labelled with an affinity purified antiserum to ubiquitin, and BF10, a monoclonal antibody to a neurofilament epitope.
Medical subject headings
- Boxing
- Brain Concussion
- Brain Damage, Chronic
- Dementia
- Frontal Lobe
- Neurofibrils
- Temporal Lobe
- Ubiquitins