Chromatin proteins do double duty.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18510918.
- Also identified by DOI 10.1016/j.cell.2008.05.011.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The histone acetyltransferase MOF (males-absent-on-the-first) is required for the regulation of X chromosome gene dosage compensation in Drosophila males. In this issue, Kind et al. (2008) show that MOF is also found on autosomes and that it has two modes of binding: one in males for X chromosome dosage compensation and the other in both sexes for X chromosome and autosomal gene regulation independent of dosage compensation.
Medical subject headings
- Dosage Compensation, Genetic
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression Regulation
- Histone Acetyltransferases
- Nuclear Proteins