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basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18510919.
- Also identified by DOI 10.1016/j.cell.2008.05.012.
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Abstract
Capping proteins limit actin filament growth, but paradoxically increase actin-based cell motility. This has been attributed to funneling of actin monomers to the filament ends that remain uncapped. Using a reconstituted motility system, Akin and Mullins (2008) now demonstrate that filament capping increases Arp2/3-based nucleation and branching, rather than elevating the rate of filament elongation.
Medical subject headings
- Actins
- Cell Movement
- Cytoskeletal Proteins