p53 regulation orchestrates the TGF-beta response.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18510920.
- Also identified by DOI 10.1016/j.cell.2008.05.013.
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Abstract
Among its multiple functions, p53 is a critical regulator of TGF-beta responses. Sasai et al. (2008) now identify a new p53 inhibitory protein, XFDL156. During embryonic development, this factor is expressed in the ectoderm germ layer and maintains the pluripotency of ectodermal cells by inhibiting TGF-beta target genes that promote mesoderm specification.
Medical subject headings
- Cell Differentiation
- Transforming Growth Factor beta
- Tumor Suppressor Protein p53
- Xenopus