Regulatory T cells and immune tolerance.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18510923.
- Also identified by DOI 10.1016/j.cell.2008.05.009.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host. Tregs are produced in the thymus as a functionally mature subpopulation of T cells and can also be induced from naive T cells in the periphery. Recent research reveals the cellular and molecular basis of Treg development and function and implicates dysregulation of Tregs in immunological disease.
Medical subject headings
- Self Tolerance
- T-Lymphocytes, Regulatory