Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18511917.
- Also identified by DOI 10.1038/nmeth.1218 and PMC identifier 3397402.
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Abstract
Single-molecule force spectroscopy has emerged as a powerful tool to investigate the forces and motions associated with biological molecules and enzymatic activity. The most common force spectroscopy techniques are optical tweezers, magnetic tweezers and atomic force microscopy. Here we describe these techniques and illustrate them with examples highlighting current capabilities and limitations.
Medical subject headings
- Magnetics
- Microscopy, Atomic Force
- Optical Tweezers
- Spectrophotometry