Web-based design and evaluation of T-cell vaccine candidates.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18515277.
- Also identified by DOI 10.1093/bioinformatics/btn251.
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Abstract
We present a suite of on-line tools to design candidate vaccine proteins, and to assess antigen potential, using coverage of k-mers (as proxies for potential T-cell epitopes) as a metric. The vaccine design tool uses the recently published 'mosaic' method to generate protein sequences optimized for coverage of high-frequency k-mers; the coverage-assessment tools facilitate coverage comparisons for any potential antigens. To demonstrate these tools, we designed mosaic protein sets for B-clade HIV-1 Gag, Pol and Nef, and compared them to antigens used in a recent human vaccine trial. http://hiv.lanl.gov/content/sequence/MOSAIC/.
Medical subject headings
- AIDS Vaccines
- HIV Infections
- HIV-1
- T-Lymphocytes
- Technology, Pharmaceutical
- Vaccines