Association of cannabis use with prodromal symptoms of psychosis in adolescence.

Miettunen, Jouko; Törmänen, Sari; Murray, Graham K; Jones, Peter B; Mäki, Pirjo; Ebeling, Hanna; Moilanen, Irma; Taanila, Anja et al. · Br J Psychiatry · 2008

cross_sectional · Level IV

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Abstract

Recent interest has focused on the association between cannabis use and risk of psychosis. In the largest unselected, population-based study on this topic to date, we examined cannabis use and prodromal symptoms of psychosis at age 15-16 years among 6330 adolescents. Those who had tried cannabis (n=352; 5.6% of the total sample) were more likely to present three or more prodromal symptoms even after controlling for confounders including previous behavioural symptoms (OR=2.23; 95% CI 1.70-2.94). A dose-response effect was seen. We conclude that cannabis use is associated with prodromal symptoms of psychosis in adolescence.

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