In vitro whole-organ imaging: 4D quantification of growing mouse limb buds.
basic_science · Level V
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- Record sourced from PubMed, PMID 18516047.
- Also identified by DOI 10.1038/nmeth.1219.
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Abstract
Quantitative mapping of the normal tissue dynamics of an entire developing mammalian organ has not been achieved so far but is essential to understand developmental processes and to provide quantitative data for computational modeling. We developed a four-dimensional (4D) imaging technique that can be used to quantitatively image tissue movements and dynamic GFP expression domains in a growing transgenic mouse limb by time-lapse optical projection tomography (OPT).
Medical subject headings
- Extremities
- Imaging, Three-Dimensional
- Tomography, Optical