Ischemia-reperfusion treatment: opportunities point to modulation of the inflammatory response.

Rouschop, K M A; Leemans, J C · Kidney Int · 2008

editorial · Level V

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Abstract

Ischemia-reperfusion injury is the leading cause of acute renal failure and determinant of renal-transplant outcome. Although many experimental studies show decreased injury and preserved renal function after dampening of the inflammatory response, surprisingly little progress has been made in the development of novel therapies.

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