IgA nephropathy: markers of progression and clues to pathogenesis.
Level V
Where this comes from
- Record sourced from PubMed, PMID 18516058.
- Also identified by DOI 10.1038/ki.2008.158.
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Abstract
The unpredictable progression of IgA nephropathy hinders its treatment. The correlation of renal dysfunction with the immunophenotype of leukocytic infiltrates revealed interstitial CD20(+) cells and tubular NKG7(+)(GMP-17(+))/CD8(+) intraepithelial cells as predictive markers of progression in early-phase IgA nephropathy. This suggests that adaptive and innate immune responses mediate progression.
Medical subject headings
- Glomerulonephritis, IGA
- Kidney Tubules