Ezetimibe blocks internalization of the NPC1L1/cholesterol complex.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18522826.
- Also identified by DOI 10.1016/j.cmet.2008.05.001.
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Abstract
Niemann-Pick C1-like 1 (NPC1L1) is a target for ezetimibe, a drug that blocks intestinal cholesterol absorption. A new study by Ge et al. (2008) in this issue of Cell Metabolism shows that non-lipoprotein-bound cholesterol induces endocytosis of NPC1L1 and that ezetimibe blocks the internalization of the NPC1L1/cholesterol complex. The in vivo significance of these findings is discussed.
Medical subject headings
- Azetidines
- Cholesterol
- Endocytosis
- Membrane Proteins