Puma: mauling the intestinal crypt.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18522842.
- Also identified by DOI 10.1016/j.stem.2008.05.014.
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Abstract
Cancer therapies utilizing chemotherapy or radiotherapy are constrained by risk of intestinal stem cell death. In this issue of Cell Stem Cell, Qiu et al. report that Puma deletion prevents intestinal degeneration following DNA damage, thus offering a target protein for the design of enhanced cancer treatments.
Medical subject headings
- Adult Stem Cells
- Apoptosis Regulatory Proteins
- Gastrointestinal Tract
- Radiation Injuries, Experimental
- Tumor Suppressor Proteins