Should we use large scale healthcare interventions without clear evidence that benefits outweigh costs and harms? Yes.

Abstract

Obtaining definitive evidence on the effects of large scale interventions can be difficult. <b>Bernard Crump </b>believes that implementation with careful monitoring is justified but <b>Seth Landefeld and colleagues (</b>doi: 10.1136/bmj.a144) argue that acting without proof of net benefit is both costly and potentially damaging to health