LOT: a tool for linkage analysis of ordinal traits for pedigree data.
other · Level V
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- Record sourced from PubMed, PMID 18535081.
- Also identified by DOI 10.1093/bioinformatics/btn258 and PMC identifier 2566542.
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Abstract
Existing linkage-analysis methods address binary or quantitative traits. However, many complex diseases and human conditions, particularly behavioral disorders, are rated on ordinal scales. Herein, we introduce, LOT, a tool that performs linkage analysis of ordinal traits for pedigree data. It implements a latent-variable proportional-odds logistic model that relates inheritance patterns to the distribution of the ordinal trait. The likelihood-ratio test is used for testing evidence of linkage. The LOT program is available for download at http://c2s2.yale.edu/software/LOT/
Medical subject headings
- Algorithms
- Chromosome Mapping
- Genetic Linkage
- Models, Genetic
- Pedigree
- Software